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Institute of Bioprocess Engineering
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Institute of Bioprocess Engineering

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Nanobiotechnology

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  • Working groups
    • Nanobiotechnology
      • Dynamic kinetic resolution
      • Encapsulation of enzymes
      • Functionalizaton of DNA nanostructures
    • Biocatalysis and fermentation
      • Novel enzymes from phototrophic microorganisms
      • Biocatalytic multi-step production of alkaloids
      • Enzymatic degradation of PET
    • Systems Biotechnology
    • Aquatic Biotechnology
      • Geobiotechnology
      • Control and combat of koi herpesvirus
      • Control and combat of fish viroses
    • Tissue Engineering
      • Regeneration of cartilage defects
    • Microencapsulation
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Nanobiotechnology

Kathrin Castiglione

Prof. Dr. Kathrin Castiglione

Head of Institute

Department of Chemical and Biological Engineering
Institute of Bioprocess Engineering

Room: Room 02.022
Paul-Gordan-Str. 3
91052 Erlangen
Germany
  • Phone number: +49 9131 85-23003
  • Email: kathrin.castiglione@fau.de
  • Website: https://www.bvt.tf.fau.eu

 

When designing a complex enzymatic synthesis process, it is ideal to combine all related enzymes catalyzing the individual reactions in a given sequence in one pot. However, in such cascades incompatibilities between individual reactions are no exception. Enzymes may be inactivated or inhibited by substrates or products, or may need quite different reaction conditions. We try to solve this problem by a nanotechnological concept: By applying nano-scale enzyme membrane reactors with highly selective permeability of their membranes, a spatial separation of incompatible reactions via compartmentalization becomes possible.

Arbeitsgruppe Nanobiotechnologie

As reaction compartments, vesicles formed from amphiphilic block polymers, so-called polymersomes, will be utilized. These vesicles typically have diameters of around 100 nm, are of substantial stability and exhibit low permeability for most substances. Thus, by inserting natural or artificial channel proteins, a highly selective mass transfer can be implemented. This way the construction of polymersomes with optimal properties for specific applications becomes possible.

 

Friedrich-Alexander-Universität Erlangen-Nürnberg
Institute of Bioprocess Engineering

Paul-Gordan-Str. 3
91052 Erlangen
Germany
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