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Institute of Bioprocess Engineering
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Institute of Bioprocess Engineering

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Biocatalysis and fermentation

In page navigation: Research
  • Working groups
    • Nanobiotechnology
      • Dynamic kinetic resolution
      • Encapsulation of enzymes
      • Functionalizaton of DNA nanostructures
    • Biocatalysis and fermentation
      • Novel enzymes from phototrophic microorganisms
      • Biocatalytic multi-step production of alkaloids
      • Enzymatic degradation of PET
    • Systems Biotechnology
    • Aquatic Biotechnology
      • Geobiotechnology
      • Control and combat of koi herpesvirus
      • Control and combat of fish viroses
    • Tissue Engineering
      • Regeneration of cartilage defects
    • Microencapsulation
  • Publications
  • PhDs since 2022

Biocatalysis and fermentation

Dr. Holger Hübner

Working group leader

Department of Chemical and Biological Engineering
Biocatalysis and Fermentation

Room: Room 01.042
Paul-Gordan-Str. 3
91052 Erlangen
Germany
  • Phone number: +49 9131 85-23006
  • Email: holger.huebner@fau.de
  • Website: https://www.bvt.tf.fau.eu

Office hours for students:

Please, contact me before via e-mail or phone to announce your coming.

Jede Woche Mo, 14:00 - 16:00,

The number of newly identified or characterized enzymes continually grows thus improving the spectrum of enzymatic reactions on a nearly daily basis. Nevertheless, from a biotechnological point of view we are far away from having available an appropriate biocatalyst for any conversion of a given substrate to a specific product. Additionally, not every available enzyme capable of catalyzing a given reaction is suitable for an industrial and economic application, due to low activity or stability. We therefore try (1) to identify new enzymes and (2) to modulate their relevant characteristics to optimize them for a technical process. But when designing biocatalysts it’s not all about modifying individual enzymes via protein engineering. Frequently, specifically tailored cell factories developed via cell engineering come into play. Whole cell catalysts can be highly attractive for biotechnology from an economical point of view. However, problems may arise due to unwanted metabolic side reactions of the cell or insufficient mass transport of necessary substrates over the cell membrane. Such limitations can be overcome by modifications of the host cell.

The application of current methods of protein engineering and cell engineering facilitate the tailored design of suitable biocatalysts for technical purposes. However, for the implementation of production processes that represent a technology comparable or even superior to traditional chemical catalysis, the sole focus on molecular characteristics is not sufficient. Bioprocess engineering is an important factor to be considered for the development of novel and optimized processes and to exploit the full potential of the employed biocatalysts.

 

Friedrich-Alexander-Universität Erlangen-Nürnberg
Institute of Bioprocess Engineering

Paul-Gordan-Str. 3
91052 Erlangen
Germany
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